Shrinkage of a Different Kind: What APOE4's Effect on Brain Cells Means for Alzheimer's Research Recent research at the Gladstone Institutes has shed new light on the molecular mechanisms underlying the APOE4 gene variant's link to Alzheimer's disease.
Published in Nature Aging, this study reveals that APOE4 drives hyperactive brain activity years before symptoms arise.
The researchers found that young mice carrying APOE4 exhibit hyperactivity even before noticeable memory problems occur.